产品名称
OSTM1 Rabbit Polyclonal Antibody (C-term)
别名
Osteopetrosis-associated transmembrane protein 1, Chloride channel 7 beta subunit, OSTM1, GL
Human Gene ID
NP_054747.2
Human Swissprot No.
Q86WC4
特异性
This OSTM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 292-321 amino acids from the C-terminal region of human OSTM1.
背景介绍
This gene encodes a protein that may be involved in the
degradation of G proteins via the ubiquitin-dependent proteasome
pathway. The encoded protein binds to members of subfamily A of the
regulator of the G-protein signaling (RGS) family through an
N-terminal leucine-rich region. This protein also has a central
RING finger-like domain and E3 ubiquitin ligase activity. This
protein is highly conserved from flies to humans. Defects in this
gene may cause the autosomal recessive, infantile malignant form of
osteopetrosis.
细胞定位
Lysosome membrane; Single-pass type I membrane protein Note=Requires CLCN7 to travel to lysosomes
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.