产品名称
ORC2 Rabbit Polyclonal Antibody
蛋白名称
Origin recognition complex subunit 2
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q13416
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q13416/entry
Mouse Swissprot No.
Q60862
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q60862
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q75PQ8
免疫原
Synthesized peptide derived from human protein . at AA range: 180-260
特异性
ORC2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and -5. It also interacts with CDC45 and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-me
信号通路
Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;
功能
function:Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner.,similarity:Belongs to the ORC2 family.,subunit:ORC is composed of six subunits. Interacts with DBF4 (By similarity). Interacts with MCM10.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
