产品名称
PPP1R3B Rabbit Polyclonal Antibody (C-term)
别名
Protein phosphatase 1 regulatory subunit 3B, Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL, Protein phosphatase 1 regulatory subunit 4, PP1 subunit R4, Protein phosphatase 1 subunit GL, PTG, PPP1R3B, PPP1R4
Human Gene ID
NP_001188258.1;NP_078883.2
Human Swissprot No.
Q86XI6
特异性
This PPP1R3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205-231 amino acids from the C-terminal region of human PPP1R3B.
背景介绍
The protein phosphatase-1 (PP1) catalytic subunit (PPP1CA;
MIM 176875) is regulated by targeting subunits, such as PP1R3B.
PP1R3B suppresses the rate at which PP1 dephosphorylates (i.e.,
inactivates) glycogen phosphorylase (see PYGL; MIM 232700) and
enhances the rate at which it activates glycogen synthase (see
GYS2; MIM 138571) (Doherty et al., 1995 [PubMed 7498521]).[supplied
by OMIM].
组织表达
Highly expressed in the liver and, at lower levels, in skeletal muscle, including in vastus lateralis, gastrocnemius and soleus (at protein level). Highest mRNA levels are observed in skeletal muscle, and only moderate levels in liver and heart. Weak expression in placenta and lung.
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
