背景介绍
This gene is a member of the cyclophilin family of
peptidylprolyl isomerases. The cyclophilins are a highly conserved
ubiquitous family, members of which play an important role in
protein folding, immunosuppression by cyclosporin A, and infection
of HIV-1 virions. This protein interacts with the proteinase
inhibitor eglin c and is localized in the nucleus. Multiple
transcript variants encoding different isoforms have been found for
this gene.
组织表达
Highest expression in thymus, pancreas and testis. Also detected in heart, placenta, lung, liver, skeletal muscle, kidney, spleen, prostate, ovary, small intestine and colon. Poorly detected in brain and leukocytes. Strong protein expression in lymph node (cortical, paracortical and medullar regions), thyroid (follicular epithelial cells), testis (developing spermatozoa), stomach (cells lining the gastric pit), pancreas, kidney (proximal and distal-tubule cells and collecting duct cells but not in glomeruli), endometrium and colon (goblet cells). Moderate protein expression in spleen, prostate (epithelium and squamous cell carcinomas), placenta and adrenal gland Weak protein expression in liver, heart, breast, ovary, and lung. No protein expression in brain and bladder. High protein expression in most lymphomas and melanomas.
