产品名称
AP3M1 Rabbit Polyclonal Antibody (C-term)
别名
AP-3 complex subunit mu-1, AP-3 adaptor complex mu3A subunit, Adaptor-related protein complex 3 subunit mu-1, Mu-adaptin 3A, Mu3A-adaptin, AP3M1
Human Gene ID
NP_036227.1;NP_996895.1
Human Swissprot No.
Q9Y2T2
特异性
This AP3M1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 390-418 amino acids from the C-terminal region of human AP3M1.
背景介绍
The protein encoded by this gene is the medium subunit of
AP-3, which is an adaptor-related protein complex associated with
the Golgi region as well as more peripheral intracellular
structures. AP-3 facilitates the budding of vesicles from the Golgi
membrane and may be directly involved in protein sorting to the
endosomal/lysosomal system. AP-3 is a heterotetrameric protein
complex composed of two large subunits (delta and beta3), a medium
subunit (mu3), and a small subunit (sigma 3). Mutations in one of
the large subunits of AP-3 have been associated with the
Hermansky-Pudlak syndrome, a genetic disorder characterized by
defective lysosome-related organelles. Alternatively spliced
transcript variants encoding the same protein have been observed.
细胞定位
Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
