产品名称
RASSF1 Rabbit Polyclonal Antibody (Center)
别名
Ras association domain-containing protein 1, RASSF1 {ECO:0000312|EMBL:AAF351282}
Human Gene ID
NP_001193886.1;NP_009113.3;NP_733830.1;NP_733831.1;NP_733832.1
Human Swissprot No.
Q9NS23
特异性
This RASSF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-132 amino acids from the Central region of human RASSF1.
背景介绍
This gene encodes a protein similar to the RAS effector
proteins. Loss or altered expression of this gene has been
associated with the pathogenesis of a variety of cancers, which
suggests the tumor suppressor function of this gene. The
inactivation of this gene was found to be correlated with the
hypermethylation of its CpG-island promoter region. The encoded
protein was found to interact with DNA repair protein XPA. The
protein was also shown to inhibit the accumulation of cyclin D1,
and thus induce cell cycle arrest. Seven alternatively spliced
transcript variants of this gene encoding distinct isoforms have
been reported.
组织表达
Isoform A and isoform C are ubiquitously expressed in all tissues tested, however isoform A is absent in many corresponding cancer cell lines. Isoform B is mainly expressed in hematopoietic cells.
细胞定位
[Isoform A]: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Nucleus Note=Localizes to cytoplasmic microtubules during interphase, to bipolar centrosomes associated with microtubules during prophase, to spindle fibers and spindle poles at metaphase and anaphase, to the midzone during early telophase, and to the midbody in late telophase in cells. Colocalizes with MDM2 in the nucleus
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
