产品名称
GEMI8 Rabbit Polyclonal Antibody
蛋白名称
Gem-associated protein 8 (Gemin-8) (Protein FAM51A1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9NWZ8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NWZ8/entry
Mouse Swissprot No.
Q8BHE1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BHE1
免疫原
Synthesized peptide derived from human protein . at AA range: 180-260
特异性
GEMI8 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. The encoded protein binds to both SMN1 and the GEMIN6/GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010],
组织表达
Colon,Gastric carcinoma,Lung,Thalamus,
细胞定位
Nucleus, gem . Cytoplasm . Found in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.
功能
function:The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus.,subcellular location:Found in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.,subunit:Part of the core SMN complex that contains SMN1, SIP1/GEMIN2, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Binds directly to SMN1 and to the GEMIN6-GEMIN7 heterodimer, mediating their interaction.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
