产品名称
MYH7 Rabbit Polyclonal Antibody (N-term)
别名
Myosin-7, Myosin heavy chain 7, Myosin heavy chain slow isoform, MyHC-slow, Myosin heavy chain, cardiac muscle beta isoform, MyHC-beta, MYH7, MYHCB
Human Gene ID
NP_000248.2
Human Swissprot No.
P12883
特异性
This MYH7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-211 amino acids from the N-terminal region of human MYH7.
背景介绍
Muscle myosin is a hexameric protein containing 2 heavy
chain subunits, 2 alkali light chain subunits, and 2 regulatory
light chain subunits. This gene encodes the beta (or slow) heavy
chain subunit of cardiac myosin. It is expressed predominantly in
normal human ventricle. It is also expressed in skeletal muscle
tissues rich in slow-twitch type I muscle fibers. Changes in the
relative abundance of this protein and the alpha (or fast) heavy
subunit of cardiac myosin correlate with the contractile velocity
of cardiac muscle. Its expression is also altered during thyroid
hormone depletion and hemodynamic overloading. Mutations in this
gene are associated with familial hypertrophic cardiomyopathy,
myosin storage myopathy, dilated cardiomyopathy, and Laing
early-onset distal myopathy.
组织表达
Both wild type and variant Gln-403 are detected in skeletal muscle (at protein level).
细胞定位
Cytoplasm, myofibril {ECO:0000250|UniProtKB:P02564}. Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:P02564}. Note=Thick filaments of the myofibrils {ECO:0000250|UniProtKB:P02564}
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
