产品名称
DDX4 Rabbit Polyclonal Antibody (N-term)
别名
Probable ATP-dependent RNA helicase DDX4, DEAD box protein 4, Vasa homolog, DDX4, VASA
Human Gene ID
NP_001136021.1;NP_001160005.1;NP_001160006.1;NP_077726.1
Human Swissprot No.
Q9NQI0
特异性
This DDX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-131 amino acids from the N-terminal region of human DDX4.
背景介绍
DEAD box proteins, characterized by the conserved motif
Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are
implicated in a number of cellular processes involving alteration
of RNA secondary structure such as translation initiation, nuclear
and mitochondrial splicing, and ribosome and spliceosome assembly.
Based on their distribution patterns, some members of this family
are believed to be involved in embryogenesis, spermatogenesis, and
cellular growth and division. This gene encodes a DEAD box protein,
which is a homolog of VASA proteins in Drosophila and several other
species. The gene is specifically expressed in the germ cell
lineage in both sexes and functions in germ cell development.
Multiple transcript variants encoding different isoforms have been
found for this gene.
组织表达
Expressed only in ovary and testis. Expressed in migratory primordial germ cells in the region of the gonadal ridge in both sexes.
细胞定位
Cytoplasm {ECO:0000250|UniProtKB:Q61496}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q61496} Note=Component of the meiotic nuage, also named P granule, a germ-cell- specific organelle required to repress transposon activity during meiosis. {ECO:0000250|UniProtKB:Q61496}
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
