产品名称
MYOT Rabbit Polyclonal Antibody (Center)
别名
Myotilin, 57 kDa cytoskeletal protein, Myofibrillar titin-like Ig domains protein, Titin immunoglobulin domain protein, MYOT, TTID
Human Gene ID
NP_001129412.1;NP_006781.1
Human Swissprot No.
Q9UBF9
特异性
This MYOT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-155 amino acids from the Central region of human MYOT.
背景介绍
This gene encodes a cystoskeletal protein which plays a
significant role in the stability of thin filaments during muscle
contraction. This protein binds F-actin, crosslinks actin
filaments, and prevents latrunculin A-induced filament disassembly.
Mutations in this gene have been associated with limb-girdle
muscular dystrophy and myofibrillar myopathies. Several
alternatively spliced transcript variants of this gene have been
described, but the full-length nature of some of these variants has
not been determined.
组织表达
Expressed in skeletal muscle (at protein level). Expressed in skeletal muscle, heart, bone marrow and thyroid gland
细胞定位
Cell membrane, sarcolemma. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=Sarcomeric, also localized to the sarcolemma (PubMed:10369880). Colocalizes with MYOZ1 at the Z-lines in skeletal muscle (PubMed:16076904).
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.