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MYOT Rabbit Polyclonal Antibody (Center)

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产品基本信息

产品货号
BD-PB1602
产品名称
MYOT Rabbit Polyclonal Antibody (Center)
别名
Myotilin, 57 kDa cytoskeletal protein, Myofibrillar titin-like Ig domains protein, Titin immunoglobulin domain protein, MYOT, TTID
类别
常规抗体
推荐应用
WB
反应种属
Human
Human Gene ID
NP_001129412.1;NP_006781.1
Human Swissprot No.
Q9UBF9
特异性
This MYOT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-155 amino acids from the Central region of human MYOT.
稀释度
WB~~1:1000
预测分子量
55kDa
同种型
Rabbit Ig
背景介绍
This gene encodes a cystoskeletal protein which plays a significant role in the stability of thin filaments during muscle contraction. This protein binds F-actin, crosslinks actin filaments, and prevents latrunculin A-induced filament disassembly. Mutations in this gene have been associated with limb-girdle muscular dystrophy and myofibrillar myopathies. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
组织表达
Expressed in skeletal muscle (at protein level). Expressed in skeletal muscle, heart, bone marrow and thyroid gland
细胞定位
Cell membrane, sarcolemma. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=Sarcomeric, also localized to the sarcolemma (PubMed:10369880). Colocalizes with MYOZ1 at the Z-lines in skeletal muscle (PubMed:16076904).
期货
现货
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

MYOT Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the MYOT antibody detected the MYOT protein (arrow).

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