产品名称
ATP2C1 Rabbit Polyclonal Antibody (C-term)
别名
Calcium-transporting ATPase type 2C member 1, ATPase 2C1, ATP-dependent Ca(2+) pump PMR1, ATP2C1, KIAA1347, PMR1L
Human Gene ID
NP_001001485.1;NP_001001486.1;NP_001001487.1;NP_001186108.1;NP_001186109.1;NP_001186110.1;NP_001186111.1;NP_001186112.1;NP_001186113.1;NP_001186114.1;NP_055197.2
Human Swissprot No.
P98194
特异性
This ATP2C1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 882-909 amino acids from the C-terminal region of human ATP2C1.
背景介绍
The protein encoded by this gene belongs to the family of
P-type cation transport ATPases. This magnesium-dependent enzyme
catalyzes the hydrolysis of ATP coupled with the transport of the
calcium. Defects in this gene cause Hailey-Hailey disease, an
autosomal dominant disorder. Alternatively spliced transcript
variants encoding different isoforms have been identified.
组织表达
Found in most tissues except colon, thymus, spleen and leukocytes (PubMed:15831496). Expressed in keratinocytes (at protein level) (PubMed:15831496, PubMed:14632183)
细胞定位
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein. Note=During neuron differentiation, shifts from juxtanuclear Golgi position to multiple Golgi structures distributed over the neural soma with a predominance in the apical dendritic trunk {ECO:0000250|UniProtKB:Q80XR2}
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
