产品名称
CDS2 Rabbit Polyclonal Antibody (Center)
别名
Phosphatidate cytidylyltransferase 2, CDP-DAG synthase 2, CDP-DG synthase 2, CDP-diacylglycerol synthase 2, CDS 2, CDP-diglyceride pyrophosphorylase 2, CDP-diglyceride synthase 2, CTP:phosphatidate cytidylyltransferase 2, CDS2
Human Gene ID
NP_003809.1
Human Swissprot No.
O95674
特异性
This CDS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-165 amino acids from the Central region of human CDS2.
背景介绍
Breakdown products of phosphoinositides are ubiquitous
second messengers that function downstream of many G
protein-coupled receptors and tyrosine kinases regulating cell
growth, calcium metabolism, and protein kinase C activity. This
gene encodes an enzyme which regulates the amount of
phosphatidylinositol available for signaling by catalyzing the
conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme
is an integral membrane protein localized to two subcellular
domains, the matrix side of the inner mitochondrial membrane where
it is thought to be involved in the synthesis of
phosphatidylglycerol and cardiolipin and the cytoplasmic side of
the endoplasmic reticulum where it functions in
phosphatidylinositol biosynthesis. Two genes encoding this enzyme
have been identified in humans, one mapping to human chromosome
4q21 and a second to 20p13.
组织表达
Widely expressed. Expressed in heart, brain and retina, and to a lesser extent in placenta, lung, liver, skeletal muscle, kidney and pancreas.
细胞定位
Endoplasmic reticulum membrane; Multi-pass membrane protein
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.