产品名称
RIC8A Rabbit Polyclonal Antibody (Center)
别名
Synembryn-A, Protein Ric-8A, RIC8A
Human Gene ID
NP_068751.4
Human Swissprot No.
Q9NPQ8
特异性
This RIC8A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 244-272 amino acids from the Central region of human RIC8A.
背景介绍
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
细胞定位
Cytoplasm. Cell membrane. Note=Colocalizes with RIC8A in CA2 hippocampal neurons Colocalizes with GNAI1 and RGS14 at the plasma membrane (By similarity).
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
