产品名称
NCYM Rabbit Polyclonal Antibody
蛋白名称
N-cym protein (N-myc opposite strand)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P40205
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P40205/entry
免疫原
Synthesized peptide derived from human protein . at AA range: 40-120
特异性
NCYM Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is transcribed in antisense to the v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog gene (MYCN). It is thought to encode a small, novel protein that stabilizes MYCN, prevents apoptosis, and promotes cell proliferation. Transcripts at this locus may also act directly as functional RNAs to recruit transcriptional regulators to the promoter of MYCN and stimulate transcription of this oncogene. This gene therefore functions through both RNA and protein products. [provided by RefSeq, Aug 2016],
组织表达
Expressed in the neuronal cells of the cerebrum and cerebellum, spermatocytes of the testis, pancreatic cells and also the heart. Expressed in both primary and metastatic neuroblastomas and in thyroid tumors (at protein level). Expression is associated with poor prognosis in neuroblastoma. Expressed in the fetal brain, lung, liver and kidney at varying low levels.
细胞定位
Cytoplasm . Nucleus .
功能
developmental stage:Expressed during fetal development, as well as in tumor cell lines containing amplified N-myc loci, where it is expressed at very high levels.,function:May have a functional role during normal fetal development.,tissue specificity:Expressed in the fetal brain, lung, liver and kidney at varying low levels.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
