产品名称
CSRP3 Rabbit Polyclonal Antibody (Center)
别名
Cysteine and glycine-rich protein 3, Cardiac LIM protein, Cysteine-rich protein 3, CRP3, LIM domain protein, cardiac, Muscle LIM protein, CSRP3, CLP, MLP
Human Gene ID
NP_003467.1
Human Swissprot No.
P50461
特异性
This CSRP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 91-119 amino acids from the Central region of human CSRP3.
背景介绍
This gene encodes a member of the CSRP family of LIM
domain proteins, which may be involved in regulatory processes
important for development and cellular differentiation. The
LIM/double zinc-finger motif found in this protein is found in a
group of proteins with critical functions in gene regulation, cell
growth, and somatic differentiation. Mutations in this gene are
thought to cause heritable forms of hypertrophic cardiomyopathy
(HCM) and dilated cardiomyopathy (DCM) in humans. Alternatively
spliced transcript variants with different 5' UTR, but encoding the
same protein, have been found for this gene.
组织表达
Cardiac and slow-twitch skeletal muscles. Isoform 2 is expressed in striated muscle. Isoform 2 is specifically expressed at higher levels in patients with neuromuscular diseases, such as limb- girdle muscular dystrophy 2A (LGMD2A), Duchenne muscular dystrophy (DMD) and dermatomyositis (PubMed:24860983)
细胞定位
Nucleus {ECO:0000250|UniProtKB:P50463}. Cytoplasm. Cytoplasm, cytoskeleton Cytoplasm, myofibril, sarcomere, Z line Cytoplasm, myofibril, sarcomere Note=Nucleocytoplasmic shuttling protein. Mainly cytoplasmic. In the Z line, found associated with GLRX3 (By similarity) {ECO:0000250|UniProtKB:P50462, ECO:0000250|UniProtKB:P50463}
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
