产品名称
RBM4 Rabbit Polyclonal Antibody (C-term)
别名
RNA-binding protein 4, Lark homolog, hLark, RNA-binding motif protein 4, RNA-binding motif protein 4a, RBM4, RBM4A
Human Gene ID
NP_001185772.1;NP_001185773.1;NP_002887.2
Human Swissprot No.
Q9BWF3
特异性
This RBM4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 334-362 amino acids from the C-terminal region of human RBM4.
背景介绍
RBM4 may play a role in alternative splice site selection during pre-mRNA processing.
组织表达
Expressed in the cerebellum. Expressed in neurons and glial cells, including layers II neurons in the frontal cortex and CA1 pyramidal neurons in the hippocampus. Expressed in heart, liver, pancreas, skeletal muscle, placenta, primary fibroblasts and peripheral blood monocytes (at protein level). Ubiquitously expressed. Highly expressed in heart, placenta and skeletal muscle. Weakly expressed in pancreas, kidney, liver, lung and brain.
细胞定位
Nucleus. Nucleus, nucleolus. Nucleus speckle. Cytoplasm. Cytoplasmic granule. Note=Undergoes continuous nucleocytoplasmic shuttling. Upon nuclear import colocalizes with SR proteins in nuclear speckles. Arsenite stress-induced phosphorylation increases its subcellular relocalization from the nucleus to the cytoplasm and to cytoplasmic stress granules (SG) via a p38 MAPK signaling pathway. Primarily localized in nucleus and nucleoli under cell growth conditions and accumulated in the cytoplasm and cytoplasm perinuclear granules upon muscle cell differentiation
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
