BD-PB1575

TNIP1 Rabbit Polyclonal Antibody (C-term)

TNFAIP3-interacting protein 1, A20-binding inhibitor of NF-kappa-B activation 1, ABIN-1, HIV-1 Nef-interacting protein, Nef-associated factor 1, Naf1, Nip40-1, Virion-associated nuclear shuttling protein, VAN, hVAN, TNIP1, KIAA0113, NAF1

常规抗体

WB

Human

NP_001239315.1;NP_001239319.1;NP_001239320.1;NP_001239321.1;NP_001239322.1;NP_001245383.1;NP_006049.3

Q15025

This TNIP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 607-636 amino acids from the C-terminal region of human TNIP1.

WB~~1:1000

72kDa

Rabbit Ig

Interacts with zinc finger protein A20/TNFAIP3 and inhibits TNF-induced NF-kappa-B-dependent gene expression by interfering with an RIP-or TRAF2-mediated transactivation signal (By similarity). Increases cell surface CD4(T4) antigen expression. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production.

Ubiquitous. Strongly expressed in peripheral blood lymphocytes, spleen and skeletal muscle, and is weakly expressed in the brain. In peripheral blood mononucleocytes, isoform 4 is mainly expressed and isoform 1 and isoform 7 are almost not expressed Expression of isoform 1 and isoform 7 increases in leukemic cells

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner

现货

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.