产品名称
SEPP1 Rabbit Polyclonal Antibody (Center)
别名
Selenoprotein P, SeP, SEPP1, SELP
Human Gene ID
NP_001078955.1;NP_005401.3
Human Swissprot No.
P49908
特异性
This SEPP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 233-262 amino acids from the Central region of human SEPP1.
背景介绍
This gene encodes a selenoprotein containing multiple
selenocysteine (Sec) residues, which are encoded by the UGA codon
that normally signals translation termination. The 3' UTR of
selenoprotein genes have a common stem-loop structure, the sec
insertion sequence (SECIS), which is necessary for the recognition
of UGA as a Sec codon rather than as a stop signal. This
selenoprotein is an extracellular glycoprotein, and is unusual in
that it contains 10 Sec residues per polypeptide. It is a
heparin-binding protein that appears to be associated with
endothelial cells, and has been implicated to function as an
antioxidant in the extracellular space. Several transcript
variants, encoding either the same or different isoform, have been
found for this gene.
组织表达
Made in the liver and heart and secreted into the plasma. It is also found in the kidney
细胞定位
Secreted. Note=Passes from plasma into the glomerular filtrate where it is removed by endocytosis mediated by LRP2 in the proximal tubule epithelium. {ECO:0000250|UniProtKB:P70274}
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
