产品名称
CARM1 Rabbit Polyclonal Antibody (Center)
别名
Histone-arginine methyltransferase CARM1, 211-, Coactivator-associated arginine methyltransferase 1, Protein arginine N-methyltransferase 4, CARM1, PRMT4
Human Gene ID
NP_954592.1
Human Swissprot No.
Q86X55
特异性
This CARM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 347-375 amino acids from the Central region of human CARM1.
背景介绍
Protein arginine N-methyltransferases, such as CARM1,
catalyze the transfer of a methyl group from
S-adenosyl-L-methionine to the side chain nitrogens of arginine
residues within proteins to form methylated arginine derivatives
and S-adenosyl-L-homocysteine. Protein arginine methylation has
been implicated in signal transduction, metabolism of nascent
pre-RNA, and transcriptional activation (Frankel et al., 2002
[PubMed 11724789]).
组织表达
Overexpressed in prostate adenocarcinomas and high- grade prostatic intraepithelial neoplasia
细胞定位
Nucleus. Cytoplasm. Note=Mainly nuclear during the G1, S and G2 phases of the cell cycle. Cytoplasmic during mitosis, after breakup of the nuclear membrane
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
