产品名称
CL12B Rabbit Polyclonal Antibody
基因名称
CLEC12B UNQ5782/PRO16089
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/387837
Human Swissprot No.
Q2HXU8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q2HXU8/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/71183
Mouse Swissprot No.
Q149M0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q149M0
免疫原
Synthesized peptide derived from human CL12B AA range: 111-161
特异性
This antibody detects endogenous levels of CL12B at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
组织表达
Detected in colon, heart, kidney, liver, lung, mammary gland, ovary, spleen and testis (PubMed:17562706). Expressed in melanocytes (at protein level) (PubMed:34310951).
细胞定位
Cell membrane ; Single-pass type II membrane protein .
功能
domain:Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,function:Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.,function:Cell surface receptor that protects target cells against natural killer cell-mediated lysis. Modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.,induction:Down-regulated in activated leukocytes recruited to a site of inflammation.,PTM:Highly N-glycosylated. Glycosylation varies between cell types.,similarity:Contains 1 C-type lectin domain.,subcellular location:Ligand binding leads to internalization.,subunit:Homodimer. Interacts with PTPN6 and PTPN11.,subunit:Interacts with PTPN6 and PTPN11.,tissue specificity:Detected in colon, heart, kidney, liver, lung, mammary gland, ovary, spleen and testis.,tissue specificity:Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
