产品名称
FBXO11 Rabbit Polyclonal Antibody (N-term)
别名
F-box only protein 11, Protein arginine N-methyltransferase 9, Vitiligo-associated protein 1, VIT-1, FBXO11, FBX11, PRMT9, VIT1
Human Gene ID
NP_001177203.1;NP_079409.3
Human Swissprot No.
Q86XK2
特异性
This FBXO11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the N-terminal region of human FBXO11.
背景介绍
This gene encodes a member of the F-box protein family
which is characterized by an approximately 40 amino acid motif, the
F-box. The F-box proteins constitute one of the four subunits of
ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),
which function in phosphorylation-dependent ubiquitination. The
F-box proteins are divided into 3 classes: Fbws containing WD-40
domains, Fbls containing leucine-rich repeats, and Fbxs containing
either different protein-protein interaction modules or no
recognizable motifs. The protein encoded by this gene belongs to
the Fbxs class. It can function as an arginine methyltransferase
that symmetrically dimethylates arginine residues, and it acts as
an adaptor protein to mediate the neddylation of p53, which leads
to the suppression of p53 function. This gene is known to be
down-regulated in melanocytes from patients with vitiligo, a skin
disorder that results in depigmentation. Polymorphisms in this gene
are associated with chronic otitis media with effusion and
recurrent otitis media (COME/ROM), a hearing loss disorder, and the
knockout of the homologous mouse gene results in the deaf mouse
mutant Jeff (Jf), a single gene model of otitis media.
Alternatively spliced transcript variants encoding distinct
isoforms have been identified for this gene.
组织表达
Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes.
细胞定位
Nucleus. Chromosome.
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
