产品名称
IKBL1 Rabbit Polyclonal Antibody
蛋白名称
NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like protein) (I-kappa-B-like protein) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9UBC1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UBC1/entry
Mouse Swissprot No.
O88995
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O88995
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q8R2H1
免疫原
Synthesized peptide derived from human protein . at AA range: 70-150
特异性
IKBL1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009],
组织表达
Detected in different cell types including monocytes, T-cells, B-cells and hepatocytes.
细胞定位
Nucleus . Nuclear localization with a speckled expression pattern in some cells. Colocalizes with CACTIN in the nucleus.
功能
disease:Mutations in the promoter region of NFKBIL1 represent the second rheumatoid arthritis susceptibility locus within the HLA region [MIM:180300].,function:May be a negative regulator of NF-kappa-B activation.,similarity:Contains 2 ANK repeats.,tissue specificity:Detected in different cell types including monocytes, T-cells, B-cells and hepatocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
