产品名称
EGLN2 Rabbit Polyclonal Antibody (N-term)
别名
Egl nine homolog 2, Estrogen-induced tag 6, HPH-3, Hypoxia-inducible factor prolyl hydroxylase 1, HIF-PH1, HIF-prolyl hydroxylase 1, HPH-1, Prolyl hydroxylase domain-containing protein 1, PHD1, EGLN2, EIT6
Human Gene ID
NP_444274.1;NP_542770.2
Human Swissprot No.
Q96KS0
特异性
This EGLN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-123 amino acids from the N-terminal region of human EGLN2.
背景介绍
The hypoxia inducible factor (HIF) is a transcriptional
complex which is involved in oxygen homeostasis. At normal oxygen
levels, the alpha subunit of HIF is targeted for degration by
prolyl hydroxylation. This gene encodes an enzyme responsible for
this posttranslational modification. Multiple alternatively spliced
variants, encoding the same protein, have been identified.
组织表达
Expressed in adult and fetal heart, brain, liver, lung, skeletal muscle, and kidney. Also expressed in testis and placenta. Highest levels in adult brain, placenta, lung, kidney, and testis. Expressed in hormone responsive tissues, including normal and cancerous mammary, ovarian and prostate epithelium
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.