产品名称
FRG1 Rabbit Polyclonal Antibody (C-term)
别名
Protein FRG1, FSHD region gene 1 protein, FRG1
Human Gene ID
NP_004468.1
Human Swissprot No.
Q14331
特异性
This FRG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 230-256 amino acids from the C-terminal region of human FRG1.
背景介绍
This gene maps to a location 100 kb centromeric of the
repeat units on chromosome 4q35 which are deleted in
facioscapulohumeral muscular dystrophy (FSHD). It is evolutionarily
conserved and has related sequences on multiple human chromosomes
but DNA sequence analysis did not reveal any homology to known
genes. In vivo studies demonstrate the encoded protein is localized
to the nucleolus.
组织表达
Expressed in adult muscle, lymphocytes, fetal brain, muscle, and placenta. Also expressed in the smooth muscle of arteries and veins, the sweat glands and the epidermis
细胞定位
Nucleus, Cajal body. Nucleus, nucleolus. Cytoplasm. Cytoplasm, myofibril, sarcomere, Z line. Note=Localization changes during myogenesis from mainly cytoplasmic in undifferentiated myoblasts, to strongly nucleolar in early myotubes and back to cytoplasmic 5 days post-differentiation (PubMed:20970242). Localized at the Z-line in the sarcomere of matured myotubes 8 days post-differentiation (PubMed:20970242).
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
