产品名称
RNF34 Rabbit Polyclonal Antibody (C-term)
别名
E3 ubiquitin-protein ligase RNF34, 632- {ECO:0000269|PubMed:25012219, ECO:0000269|Ref13}, Caspase regulator CARP1, Caspases-8 and -10-associated RING finger protein 1, CARP-1, FYVE-RING finger protein Momo, RNF34 (
HGNC:17297)
Human Gene ID
NP_001243787.1;NP_079402.2;NP_919247.1
Human Swissprot No.
Q969K3
特异性
This RNF34 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-311 amino acids from the C-terminal region of human RNF34.
背景介绍
The protein encoded by this gene contains a RINF finger, a
motif known to be involved in protein-protein and protein-DNA
interactions. This protein interacts with DNAJA3/hTid-1, which is a
DnaJ protein reported to function as a modulator of apoptosis.
Overexpression of this gene in Hela cells was shown to confer the
resistance to TNF-alpha induced apoptosis, suggesting an
anti-apoptotic function of this protein. This protein can be
cleaved by caspase-3 during the induction of apoptosis.
Alternatively spliced transcript variants encoding distinct
isoforms have been reported.
组织表达
Ubiquitous. Detected in heart, brain, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, colon and leukocytes.
细胞定位
Cell membrane; Peripheral membrane protein. Endomembrane system {ECO:0000250|UniProtKB:Q6AYH3}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6AYH3}. Nucleus Nucleus speckle. Cytoplasm, cytosol
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
