产品名称
SNUPN Rabbit Polyclonal Antibody (Center)
别名
Snurportin-1, RNA U transporter 1, SNUPN, RNUT1, SPN1
Human Gene ID
NP_001036046.1;NP_001036053.1;NP_005692.1
Human Swissprot No.
O95149
特异性
This SNUPN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 200-228 amino acids from the Central region of human SNUPN.
背景介绍
The nuclear import of the spliceosomal snRNPs U1, U2, U4
and U5, is dependent on the presence of a complex nuclear
localization signal. The latter is composed of the
5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U
snRNA and the Sm core domain. The protein encoded by this gene
interacts specifically with m3G-cap and functions as an
snRNP-specific nuclear import receptor. Alternatively spliced
transcript variants encoding the same protein have been identified
for this gene.
细胞定位
Nucleus. Cytoplasm Note=Nucleoplasmic shuttling protein. Its nuclear import involves the nucleocytoplasmic transport receptor importin beta (PubMed:10209022, PubMed:12095920). It is re-exported to the cytoplasm by the XPO1- dependent nuclear export receptor pathway (PubMed:10209022)
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
