BD-PB1531

DNMT3L Rabbit Polyclonal Antibody (C-term)

DNA (cytosine-5)-methyltransferase 3-like, DNMT3L

常规抗体

WB

Human

NP_037501.2;NP_787063.1

Q9UJW3

This DNMT3L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 355-381 amino acids from the C-terminal region of human DNMT3L.

WB~~1:1000

44kDa

Rabbit Ig

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases. This protein is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, this protein does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and it is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternative splicing results in two transcript variants. An additional splice variant has been described but its biological validity has not been determined.

Expressed at low levels in several tissues including testis, ovary, and thymus.

Nucleus.

现货

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.