产品名称
DEF6 Rabbit Polyclonal Antibody (C-term)
别名
Differentially expressed in FDCP 6 homolog, DEF-6, IRF4-binding protein, DEF6, IBP
Human Gene ID
NP_071330.3
Human Swissprot No.
Q9H4E7
特异性
This DEF6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 500-528 amino acids from the C-terminal region of human DEF6.
背景介绍
DEF6, or IBP, is a guanine nucleotide exchange factor
(GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly
expressed in B and T cells (Gupta et al., 2003 [PubMed
12923183]).
组织表达
Broadly expressed in the immune system and can be detected in T and B-cells.
细胞定位
Cytoplasm. Cell membrane Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell projection, filopodium. Note=Recruited to the plasma membrane upon binding phosphatidylinositol 3,4,5-trisphosphate (PubMed:15023524). Binds to actin filaments (PubMed:15023524)
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
