产品名称
PKD2L1 Rabbit Polyclonal Antibody (N-term)
别名
Polycystic kidney disease 2-like 1 protein, Polycystin-2 homolog, Polycystin-2L1, Polycystin-L, Polycystin-L1, PKD2L1, PKD2L, PKDL, TRPP3
Human Gene ID
NP_001240766.1;NP_057196.2
Human Swissprot No.
Q9P0L9
特异性
This PKD2L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human PKD2L1.
背景介绍
PKD2L1 is a member of the polycystin protein
family. The encoded protein contains multiple transmembrane
domains, and cytoplasmic N- and C-termini. The protein may be an
integral membrane protein involved in cell-cell/matrix
interactions. This protein functions as a calcium-regulated
nonselective cation channel. Alternative splice variants have been
described but their full length sequences have not been determined.
组织表达
Detected in taste bud cells in fungiform papillae (at protein level) (PubMed:19812697). Ubiquitous (PubMed:9748274) Expressed in adult heart, skeletal muscle, brain, spleen, testis, retina and liver (PubMed:9748274, PubMed:9878261). Isoform 4 appears to be expressed only in transformed lymphoblasts
细胞定位
Cell projection, cilium membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle {ECO:0000250|UniProtKB:A2A259}. Note=Interaction with PKD1 or PKD1L3 is required for localization to the cell membrane {ECO:0000250|UniProtKB:A2A259}
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
