产品名称
TEC Rabbit Polyclonal Antibody (N-term)
别名
Tyrosine-protein kinase Tec, TEC, PSCTK4
Human Gene ID
NP_003206.2
Human Swissprot No.
P42680
特异性
This TEC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the N-terminal region of human TEC.
背景介绍
TEC belongs to the Tec family
of non-receptor protein-tyrosine kinases containing a pleckstrin
homology domain. Tec family kinases are involved in the
intracellular signaling mechanisms of cytokine receptors,
lymphocyte surface antigens, heterotrimeric G-protein coupled
receptors, and integrin molecules. They are also key players in the
regulation of the immune functions. Tec kinase is an integral
component of T cell signaling and has a distinct role in T cell
activation. This gene may be associated with myelodysplastic
syndrome.
组织表达
Expressed in a wide range of cells, including hematopoietic cell lines like myeloid, B-, and T-cell lineages
细胞定位
Cytoplasm. Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Following B-cell or T-cell receptors activation by antigen, translocates to the plasma membrane through its PH domain. Thrombin and integrin engagement induces translocation of TEC to the cytoskeleton during platelet activation. In cardiac myocytes, assumes a diffuse intracellular localization under basal conditions but is recruited to striated structures upon various stimuli, including ATP (By similarity).
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
