产品名称
EIF3C Rabbit Polyclonal Antibody (Center)
别名
Eukaryotic translation initiation factor 3 subunit C {ECO:0000255|HAMAP-Rule:MF_03002}, eIF3c {ECO:0000255|HAMAP-Rule:MF_03002}, Eukaryotic translation initiation factor 3 subunit 8 {ECO:0000255|HAMAP-Rule:MF_03002}, eIF3 p110 {ECO:0000255|HAMAP-Rule:MF_03002}, EIF3C {ECO:0000255|HAMAP-Rule:MF_03002}
Human Gene ID
NP_001032897.1;NP_001186071.1;NP_001254503.1;NP_003743.1
Human Swissprot No.
Q99613
特异性
This EIF3C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 538-566 amino acids from the Central region of human EIF3C.
背景介绍
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
细胞定位
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03002}.
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
