产品名称
TMOD1 Rabbit Polyclonal Antibody (Center)
别名
Tropomodulin-1, Erythrocyte tropomodulin, E-Tmod, TMOD1, D9S57E, TMOD
Human Gene ID
NP_001159588.1;NP_003266.1
Human Swissprot No.
P28289
特异性
This TMOD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 170-198 amino acids from the Central region of human TMOD1.
背景介绍
TMOD1 is a member of the tropomodulin family. The
encoded protein is an actin-capping protein that regulates
tropomyosin by binding to its N-terminus, inhibiting
depolymerization and elongation of the pointed end of actin
filaments and thereby influencing the structure of the erythrocyte
membrane skeleton. Multiple transcript variants encoding the same
protein have been found for this gene.
组织表达
Highly expressed in the erythrocyte, heart and skeletal muscle
细胞定位
Cytoplasm, cytoskeleton. Note=In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments (PubMed:25250574).
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.