BD-PB1461-ZIC1 Rabbit Polyclonal Antibody (N-term)-现货抗体产品库武汉枢密脑科学技术有限公司

ZIC1 Rabbit Polyclonal Antibody (N-term)

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产品基本信息

产品货号

BD-PB1461

产品名称

ZIC1 Rabbit Polyclonal Antibody (N-term)

别名

Zinc finger protein ZIC 1, Zinc finger protein 201, Zinc finger protein of the cerebellum 1, ZIC1, ZIC, ZNF201

类别

常规抗体

推荐应用

反应种属

Human, Mouse

Human Gene ID

NP_003403.2

Human Swissprot No.

Q15915

特异性

This ZIC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-34 amino acids from the N-terminal region of human ZIC1.

稀释度

WB~~1:1000

预测分子量

48kDa

同种型

Rabbit Ig

背景介绍

This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene.

组织表达

CNS. A high level expression is seen in the cerebellum. Detected in the nuclei of the cerebellar granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the internal granular layer. Detected in medulloblastoma (26/29 cases), but not present in all other tumors examined.

细胞定位

Nucleus. Cytoplasm. Note=Localizes in the cytoplasm in presence of MDFIC overexpression.

期货

现货

纯化

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

All lanes : Anti-ZIC1 Antibody (N-term) at 1:2000 dilution Lane 1: Jurkat whole cell lysates Lane 2: SH-SY5Y whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 48 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

ZIC1 Antibody (N-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the ZIC1 antibody detected the ZIC1 protein (arrow).