产品名称
TNNI2 Rabbit Polyclonal Antibody (N-term)
别名
Troponin I, fast skeletal muscle, Troponin I, fast-twitch isoform, TNNI2
Human Gene ID
NP_001139301.1;NP_001139313.1;NP_003273.1
Human Swissprot No.
P48788
特异性
This TNNI2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human TNNI2.
背景介绍
This gene encodes a fast-twitch skeletal muscle protein, a
member of the troponin I gene family, and a component of the
troponin complex including troponin T, troponin C and troponin I
subunits. The troponin complex, along with tropomyosin, is
responsible for the calcium-dependent regulation of striated muscle
contraction. Mouse studies show that this component is also present
in vascular smooth muscle and may play a role in regulation of
smooth muscle function. In addition to muscle tissues, this protein
is found in corneal epithelium, cartilage where it is an inhibitor
of angiogenesis to inhibit tumor growth and metastasis, and mammary
gland where it functions as a co-activator of estrogen
receptor-related receptor alpha. This protein also suppresses tumor
growth in human ovarian carcinoma. Mutations in this gene cause
myopathy and distal arthrogryposis type 2B. Alternatively spliced
transcript variants have been found for this gene. [provided by
RefSeq].
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
