BD-PB1452

Connexin 31 Rabbit Polyclonal Antibody (C-term)

Gap junction beta-3 protein, Connexin-31, Cx31, GJB3, CX31

常规抗体

WB

Human

NP_001005752.1;NP_076872.1

O75712

This Connexin 31 Antibody antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 204~233 amino acids from the C-terminal region of human GJB3.

WB~~1:1000

31kDa

Rabbit Ig

Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels. Defects in GJB3 have been linked to erythrokeratodermia variabilis (EKV) is an autosomal dominant genodermatosis characterized by transient figurate red patches or hyperkeratosis. Mutations in GJB2 have also been associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction

现货

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.