BD-PB1449

Mouse TLR8 Rabbit Polyclonal Antibody (C-term)

Toll-like receptor 8, CD288, Tlr8

常规抗体

WB

Mouse

P58682

NP_573475.2

This Mouse TLR8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 957-987 amino acids from the C-terminal region of mouse TLR8.

WB~~1:1000;IHC-P~~1:100~500

119kDa

Rabbit Ig

TLR8 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR8 is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.

Endosome membrane {ECO:0000250|UniProtKB:Q9NR97}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9NR97} Note=Endosomal localization confers distinctive proteolytic processing {ECO:0000250|UniProtKB:Q9NR97}

现货

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.