产品名称
MOV10 Rabbit Polyclonal Antibody (N-term)
别名
Putative helicase MOV-10, Moloney leukemia virus 10 protein, MOV10, KIAA1631
Human Gene ID
NP_001123551.1;NP_066014.1
Human Swissprot No.
Q9HCE1
特异性
This MOV10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 260-288 amino acids from the N-terminal region of human MOV10.
稀释度
WB~~1:1000;IHC-P~~1:100~500
背景介绍
Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription.
细胞定位
Cytoplasm, P-body. Cytoplasm, Cytoplasmic ribonucleoprotein granule. Cytoplasm, Stress granule. Nucleus {ECO:0000250|UniProtKB:P23249} Cytoplasm {ECO:0000250|UniProtKB:P23249}. Note=Co-enriched in cytoplasmic foci with TUT4 (PubMed:30122351). In developing neurons, localizes both in nucleus and cytoplasm, but in the adulthood it is only cytoplasmic (By similarity). After infection, relocalizes to the DENV replication complex in perinuclear regions (PubMed:27974568) {ECO:0000250|UniProtKB:P23249, ECO:0000269|PubMed:27974568, ECO:0000269|PubMed:30122351}
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
