产品名称
CCT4 Rabbit Polyclonal Antibody (N-term)
别名
T-complex protein 1 subunit delta, TCP-1-delta, CCT-delta, Stimulator of TAR RNA-binding, CCT4, CCTD, SRB
Human Gene ID
NP_001243650.1;NP_006421.2
Human Swissprot No.
P50991
特异性
This CCT4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-32 amino acids from the N-terminal region of human CCT4.
稀释度
WB~~1:1000;IHC-P~~1:100~500
背景介绍
The chaperonin containing TCP1 (MIM 186980) complex (CCT),
also called the TCP1 ring complex, consists of 2 back-to-back
rings, each containing 8 unique but homologous subunits, such as
CCT4. CCT assists the folding of newly translated polypeptide
substrates through multiple rounds of ATP-driven release and
rebinding of partially folded intermediate forms. Substrates of CCT
include the cytoskeletal proteins actin (see MIM 102560) and
tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330)
(Won et al., 1998 [PubMed 9819444]).
细胞定位
Cytoplasm. Melanosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:P80315} Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
