产品名称
HYAL1 Rabbit Polyclonal Antibody (C-term)
别名
Hyaluronidase-1, Hyal-1, Hyaluronoglucosaminidase-1, Lung carcinoma protein 1, LuCa-1, HYAL1, LUCA1
Human Gene ID
NP_149349.2;NP_695013.1;NP_695014.1;NP_695015.1;NP_695017.1
Human Swissprot No.
Q12794
特异性
This HYAL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 280-309 amino acids from the C-terminal region of human HYAL1.
稀释度
WB~~1:1000;IHC-P~~1:100~500
背景介绍
This gene encodes a lysosomal hyaluronidase.
Hyaluronidases intracellularly degrade hyaluronan, one of the major
glycosaminoglycans of the extracellular matrix. Hyaluronan is
thought to be involved in cell proliferation, migration and
differentiation. This enzyme is active at an acidic pH and is the
major hyaluronidase in plasma. Mutations in this gene are
associated with mucopolysaccharidosis type IX, or hyaluronidase
deficiency. The gene is one of several related genes in a region of
chromosome 3p21.3 associated with tumor suppression. Multiple
transcript variants encoding different isoforms have been found for
this gene.
组织表达
Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues.
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
