产品名称
FDPS Rabbit Polyclonal Antibody (N-term)
别名
Farnesyl pyrophosphate synthase, FPP synthase, FPS, (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase, FDPS, FPS, KIAA1293
Human Gene ID
NP_001129293.1;NP_001129294.1;NP_001229753.1;NP_001229754.1;NP_001995.1
Human Swissprot No.
P14324
特异性
This FDPS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-82 amino acids from the N-terminal region of human FDPS.
背景介绍
This gene encodes an enzyme that catalyzes the production
of geranyl pyrophosphate and farnesyl pyrophosphate from
isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The
resulting product, farnesyl pyrophosphate, is a key intermediate in
cholesterol and sterol biosynthesis, a substrate for protein
farnesylation and geranylgeranylation, and a ligand or agonist for
certain hormone receptors and growth receptors. Drugs that inhibit
this enzyme prevent the post-translational modifications of small
GTPases and have been used to treat diseases related to bone
resorption. Multiple pseudogenes have been found on chromosomes 1,
7, 14, 15, 21 and X. Multiple transcript variants encoding
different isoforms have been found for this gene.
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
