产品名称
TNIK Rabbit Polyclonal Antibody
蛋白名称
TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9UKE5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UKE5/entry
Mouse Swissprot No.
P83510
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P83510
免疫原
Synthesized peptide derived from human protein . at AA range: 350-430
特异性
TNIK Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008],
组织表达
Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues.
细胞定位
Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 CNH domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with TRAF2 and NCK.,tissue specificity:Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
