BD-PB1389-PDE8A Rabbit Polyclonal Antibody (Center) (L572)-现货抗体产品库武汉枢密脑科学技术有限公司

PDE8A Rabbit Polyclonal Antibody (Center) (L572)

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产品基本信息

产品货号

BD-PB1389

产品名称

PDE8A Rabbit Polyclonal Antibody (Center) (L572)

别名

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, PDE8A

类别

常规抗体

推荐应用

反应种属

Human

Human Gene ID

NP_001230066.1;NP_002596.1;NP_775656.1

Human Swissprot No.

O60658

特异性

This PDE8A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 557-587 amino acids from the Central region of human PDE8A.

稀释度

WB~~1:1000;IHC-P~~1:100~500

预测分子量

93kDa

同种型

Rabbit Ig

背景介绍

PDE8A plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase, which has a high affinity for cAMP, may be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.

组织表达

Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon

期货

现货

纯化

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Western blot analysis of PDE8A Antibody (Center) (L572) in HL60 cell line lysates (35ug/lane). PDE8A (arrow) was detected using the purified Pab.

Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with PDE8A antibody (Center) (L572), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.