产品名称
Mouse Epha2 Rabbit Polyclonal Antibody (Center)
别名
Ephrin type-A receptor 2, Epithelial cell kinase, Tyrosine-protein kinase receptor ECK, Tyrosine-protein kinase receptor MPK-5, Tyrosine-protein kinase receptor SEK-2, Epha2, Eck, Myk2, Sek2
Human Swissprot No.
Q03145
Mouse Gene ID
NP_034269.2
特异性
This Mouse Epha2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-323 amino acids from the Central region of mouse Epha2.
背景介绍
Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A3, -A4 and -A5. Induces apoptosis in a TP53/p53-independent, caspase-8-dependent manner (By similarity). Plays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. May be involved in cell-cell interactions guiding early hindbrain development.
组织表达
Expressed in the lung, intestine and liver (PubMed:11287184). Expressed in myogenic progenitor cells (PubMed:27446912).
细胞定位
Cell membrane {ECO:0000250|UniProtKB:P29317}; Single-pass type I membrane protein. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:P29317}; Single-pass type I membrane protein. Cell projection, lamellipodium membrane {ECO:0000250|UniProtKB:P29317}; Single-pass type I membrane protein. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P29317}. Note=Present at regions of cell-cell contacts but also at the leading edge of migrating cells. Relocates from the plasma membrane to the cytoplasmic and perinuclear regions in cancer cells. {ECO:0000250|UniProtKB:P29317}
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
