产品名称
CRADD Rabbit Polyclonal Antibody
蛋白名称
Death domain-containing protein CRADD (Caspase and RIP adapter with death domain) (RIP-associated protein with a death domain)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P78560
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P78560/entry
Mouse Swissprot No.
O88843
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O88843
免疫原
Synthesized peptide derived from human protein . at AA range: 30-110
特异性
CRADD Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with mental retardation. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],
组织表达
Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney.
细胞定位
Cytoplasm . Nucleus .
功能
domain:Contains a death domain involved in the binding of RIP protein.,domain:The CARD domain mediates the interaction with caspase-2.,function:Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruites caspase-2 to the TNFR-1 signalling complex.,similarity:Contains 1 CARD domain.,similarity:Contains 1 death domain.,subunit:Interacts with LRDD.,tissue specificity:Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
