产品名称
UT2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8170
Human Swissprot No.
Q15849
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q15849/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/27411
Mouse Swissprot No.
Q8R4T9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R4T9
Rat Gene Link
https://www.uniprot.org/uniprot/54302
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q62668
免疫原
Synthesized peptide derived from human UT2 AA range: 429-479
特异性
This antibody detects endogenous levels of UT2 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the urea transporter family. In mammalian cells, urea is the chief end product of nitrogen catabolism, and plays an important role in the urinary concentration mechanism. This protein is expressed in the inner medulla of the kidney, and mediates rapid transepithelial urea transport across the inner medullary collecting duct. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011],
组织表达
Isoform 1 and isoform 2 are expressed in the inner medulla of the kidney.
细胞定位
Apical cell membrane; Multi-pass membrane protein.
功能
function:Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism.,induction:Isoform 1 is induced by low protein in the diet, isoform 2 by dehydration.,similarity:Belongs to the urea transporter family.,subunit:Isoform 1 interacts with SNAPIN which may be important for recruitment to the plasma membrane.,tissue specificity:Isoform 1 and isoform 2 are expressed in the inner medulla of the kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
