BD-PB1367-EPM2A Rabbit Polyclonal Antibody (C-term)-现货抗体产品库武汉枢密脑科学技术有限公司

EPM2A Rabbit Polyclonal Antibody (C-term)

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产品基本信息

产品货号

BD-PB1367

产品名称

EPM2A Rabbit Polyclonal Antibody (C-term)

别名

Laforin, 313-, Glucan phosphatase, Lafora PTPase, LAFPTPase, EPM2A

类别

常规抗体

推荐应用

反应种属

Human

Human Gene ID

NP_001018051.1;NP_005661.1

Human Swissprot No.

O95278

特异性

This EPM2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 288-317 amino acids from the C-terminal region of human EPM2A.

稀释度

WB~~1:1000;IHC-P~~1:100~500

预测分子量

37kDa

同种型

Rabbit Ig

背景介绍

EPM2A is a dual-specificity phosphatase that associates with polyribosomes. The encoded protein may be involved in the regulation of glycogen metabolism. Mutations have been associated with myoclonic epilepsy of Lafora.

组织表达

Expressed in heart, skeletal muscle, kidney, pancreas and brain. Isoform 4 is also expressed in the placenta

细胞定位

Cytoplasm. Note=Under glycogenolytic conditions localizes to the nucleus [Isoform 2]: Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane. Nucleus. Note=Also found in the nucleus. [Isoform 5]: Cytoplasm. Nucleus

期货

现货

纯化

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Western blot analysis of EPM2A (arrow) using rabbit polyclonal EPM2A Antibody (C-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the EPM2A gene (Lane 2) .

Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with EPM2A antibody (C-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.