产品名称
NHEJ1 Rabbit Polyclonal Antibody (C-term)
别名
Non-homologous end-joining factor 1, Protein cernunnos, XRCC4-like factor, NHEJ1, XLF
Human Gene ID
NP_079058.1
Human Swissprot No.
Q9H9Q4
特异性
This NHEJ1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 268-296 amino acids from the C-terminal region of human NHEJ1.
背景介绍
Double-strand breaks in DNA result from genotoxic stresses
and are among the most damaging of DNA lesions. This gene encodes a
DNA repair factor essential for the nonhomologous end-joining
pathway, which preferentially mediates repair of double-stranded
breaks. Mutations in this gene cause different kinds of severe
combined immunodeficiency disorders.
组织表达
Ubiquitously expressed.
细胞定位
Nucleus. Chromosome. Note=Localizes to site of double-strand breaks; recruitment is dependent on XRCC5-XRCC6 (Ku) heterodimer
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
