产品名称
CCNB2 Rabbit Polyclonal Antibody
蛋白名称
G2/mitotic-specific cyclin-B2
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O95067
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O95067/entry
Mouse Swissprot No.
P30276
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P30276
免疫原
Synthesized peptide derived from human protein . at AA range: 60-140
特异性
CCNB2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. [provided by RefSeq, Jul 2008],
组织表达
Brain,Coronary artery,Testis,
细胞定位
nucleus,nucleoplasm,centrosome,cytosol,cell-cell adherens junction,microtubule cytoskeleton,membrane,
信号通路
Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;Oocyte meiosis;p53;Progesterone-mediated oocyte maturation;
功能
developmental stage:Accumulates steadily during G2 and is abruptly destroyed at mitosis.,function:Essential for the control of the cell cycle at the G2/M (mitosis) transition.,similarity:Belongs to the cyclin family.,similarity:Belongs to the cyclin family. Cyclin AB subfamily.,subunit:Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
