产品名称
METAP2 Rabbit Polyclonal Antibody (N-term)
别名
Methionine aminopeptidase 2 {ECO:0000255|HAMAP-Rule:MF_03175}, MAP 2 {ECO:0000255|HAMAP-Rule:MF_03175}, MetAP 2 {ECO:0000255|HAMAP-Rule:MF_03175}, 341118 {ECO:0000255|HAMAP-Rule:MF_03175}, Initiation factor 2-associated 67 kDa glycoprotein {ECO:0000255|HAMAP-Rule:MF_03175}, p67 {ECO:0000255|HAMAP-Rule:MF_03175}, p67eIF2 {ECO:0000255|HAMAP-Rule:MF_03175}, Peptidase M {ECO:0000255|HAMAP-Rule:MF_03175}, METAP2 {ECO:0000255|HAMAP-Rule:MF_03175}
Human Gene ID
NP_006829.1
Human Swissprot No.
P50579
特异性
This METAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-61 amino acids from the N-terminal region of human METAP2.
背景介绍
This gene is a member of the methionyl aminopeptidase
family and encodes a protein that binds 2 cobalt or manganese ions.
This protein functions both by protecting the alpha subunit of
eukaryotic initiation factor 2 from inhibitory phosphorylation and
by removing the amino-terminal methionine residue from nascent
protein. Increased expression of this gene is associated with
various forms of cancer and the anti-cancer drugs fumagillin and
ovalicin inhibit the protein by irreversibly binding to its active
site. A pseudogene of this gene is located on chromosome 2.
细胞定位
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:21537465}. Note=About 30% of expressed METAP2 associates with polysomes
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
