产品名称
GTF2A1L Rabbit Polyclonal Antibody (C-term)
别名
TFIIA-alpha and beta-like factor, General transcription factor II A, 1-like factor, GTF2A1L, ALF, GTF2A1LF
Human Gene ID
NP_001180416.1;NP_006863.2
Human Swissprot No.
Q9UNN4
特异性
This GTF2A1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 399-428 amino acids from the C-terminal region of human GTF2A1L.
背景介绍
The assembly and stability of the RNA polymerase II
transcription pre-initiation complex on a eukaryotic core promoter
involve the effects of TFIIA on the interaction between
TATA-binding protein (TBP) and DNA. This gene encodes a germ
cell-specific counterpart of the large (alpha/beta) subunit of
general transcription factor TFIIA that is able to stabilize the
binding of TBP to DNA and may be uniquely important to testis
biology. Alternative splicing for this locus has been observed and
two variants, encoding distinct isoforms, have been identified.
Co-transcription of this gene and the neighboring upstream gene
generates a rare transcript (SALF), which encodes a fusion protein
comprised of sequence sharing identity with each individual gene
product.
组织表达
Testis specific. Detected in adult testis mostly in round and elongating spermatids (at protein level). Detected in testis
细胞定位
Nucleus. Note=Mainly localizes in the annulus and partly in acrosomal cap area of spermatozoa
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
